Glass reactor kettle structure can be designed as single, double and triple layer types. The reaction liquid can be put into the inner layer for stirring, and the middle layer can be connected with cold and hot sources (frozen liquid, hot water or hot oil) for circulating heating or cooling reaction. Under constant temperature setting, the reaction can be stirred under atmospheric or negative pressure conditions in a closed glass reactor according to the operation, and the reaction solution can also be refluxed and distilled. This machine is the ideal production equipment for modern fine chemistry, pharmaceutical and biosynthesis of new materials.